Reponse:
The following items were selected for defining response to treatment:
- Slit lamp evaluation : total number of anterior chamber cells (AC) – expressed on a VAS 0- 100
- Slit lamp evaluation: AC cells before pupil dilatation
- Grade of AC flare according SUN criteria
- Change in visual acuity – without operation – (provided in logMAR, independently of the charts used)
- Occurrence and course of structural complications:
- occurrence new posterior synechia
- Change of Optic disc edema
- Change of Macular edema
- Change of Vitreous haze
- VAS score of 0 to 100 score for uveitis activity in the worst eye in the last 4 weeks ( assessed by ophthalmologist)
- Has your eyes caused a problems in the last 4 weeks?
expressed on a VAS score of 0-100
(assessed by patients / or under the age of 8 years by the parents)
- How do you judge your eye disease during the last 3 months?
Lot better / something better/ stable/ something worst/ lot worst
(assessed by patients / or under the age of 8 years by the parents) - Change of the score of the quality of life in an Uveitis specific quality of life instrument research item
- How did you eye improved under treatment at the last three months? Expressed VAS score of 0-100
- Missed work/school /kindergarten days– due of the uveitis
- Change in CHQ/PedsQl score
Inactivity:
The following items were selected to define inacitivity. It is required, that in both eyes the following condition is reached:
- Slit lamp total number of AC cells: 0 inflammatory cells
*In aphakic patients ,some cells may be present, in the anterior vitreous - Absence of Optic disc edema
*The presence of isolated optic disc edema may not be a sign of activity - Absence Macular edema
*The presence of isolated macular edema may not be a sign of activity - Absence of Vitreous haze
*The presence of isolated vitreous haze may not be a sign of activity - VAS score of activity physician 0-100: must be 0
Remission:
The following items were selected to define remission of JIA associated uveitis on medication or off medication. It is required, that in both eyes the following condition is reached and the condition last at least 6 months on medication , or inactive disease for ≥ 3 months after discontinuing all treatments .
- Slit lamp total number of AC cells: no inflammatory cells
*In aphakic patients some cells may be present in the anterior vitreous - Absence of optic disc edema
*The presence of isolated optic disc edema may not be a sign of activity - Absence of macular edema
*The presence of isolated macular edema may not be a sign of activity - Absence of vitreous haze
*The presence of isolated vitreous haze may not be a sign of activity - VAS score of activity by the physician 0-100: must be 0
Damage:
Following items were selected for assessing damage:
Vision related permanent damage per eye /per patient – yes / no
Right eye Left eye
- flare
- synechiae
- cataract
- maculopathy
- Opticopathy
- Decreased Visual acuity
- Ocular hypertony – >21 mmHg
- Ocular hypotony – <6 mmHg
- Glaucomatous field loss and /or glaucomatous optic atrophy
- Band-keratopathy
- Epiretinal membrane formation
- Visual deterioration – less then 0.3 in any eye
- Uveitis related disability VAS 0-100 by ophthlamologist
- Uveitis related disability VAS 0-100 by pediatric rheumatologist